|Parents||Pelias and Phylomache|
|Titles||Princess of Iolcus, Queen of Iolcus|
Amphinome was the daughter of Pelias, the king of Iolcus and his wife Phylomache, one of the Niobids. Sometime after her birth, Phylomache was killed by Artemis (as punishment for Niobe boasting). She was married to Aeson, the son of Cretheus, the founder of Iolcus, who was driven from his throne by Pelias. By Aeson she became the mother of Jason and Promachus. Jason was later sent to retrieve the golden fleece, leaving his family behind. Aeson was later persecuted and he, along with Promachus, were both killed.
When Jason and Medea returned, Pelias still refused to give up his throne. Medea conspired to have Pelias' own daughters (The Peliades) kill him. She told them she could turn an old ram into a young ram by cutting up the old ram and boiling it. During the demonstration, a live, young ram jumped out of the pot. Excited, the girls cut their father into pieces and threw them in a pot, in the expectation that he would emerge rejuvenated. Pelias, of course, did not survive. As he was now an accessory to a terrible crime, Jason was still not made king. Amphinome's brother Acastus later drove Jason and Medea to Corinth and so reclaimed the kingdom.